Tfpi - tissue factor pathway inhibitor

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of blood coagulation. Predicted to act upstream of or within blood coagulation. Located in extracellular space. Is expressed in several structures, including central nervous system; hemolymphoid system; liver; lung; and retina. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor). [provided by Alliance of Genome Resources, Apr 2022]