Zeb1 - zinc finger E-box binding homeobox 1

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of neuron differentiation. Acts upstream of or within several processes, including embryonic organ morphogenesis; regulation of T cell differentiation in thymus; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; embryo mesoderm; and genitourinary system. Used to study tropical spastic paraparesis. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]