Enables tRNA binding activity. Involved in selenocysteine incorporation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; musculoskeletal system; and respiratory system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2D. Orthologous to human SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase). [provided by Alliance of Genome Resources, Apr 2022]