Predicted to enable several functions, including STAT family protein binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein ligase binding activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein localization; and protein ubiquitination. Predicted to act upstream of or within several processes, including DNA repair; chromatin organization; and defense response to other organism. Predicted to be located in cytosol; lysosome; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Predicted to colocalize with early endosome. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and oral cavity. Orthologous to human DTX3L (deltex E3 ubiquitin ligase 3L). [provided by Alliance of Genome Resources, Apr 2022]