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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Stk11 - serine/threonine kinase 11
Alias:
Lkb1
Par-4
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码丝氨酸/苏氨酸激酶家族的一员。编码的蛋白质是一种已知的肿瘤抑制子,通过磷酸化激活腺苷酸单磷酸激活的蛋白激酶(AMPK)和AMPK相关激酶蛋白质。AMPK途径的上游调节被认为可以调节许多不同的过程,包括细胞代谢、细胞极性、凋亡和DNA损伤反应。人类中类似基因的突变与Peutz-Jeghers综合症有关。可选的剪接导致多个转录变异体,包括在精子发生中可能发挥潜在作用的S异构体。[由RefSeq,2014年9月提供]
Related ID:
NCBI:20869
ENSEMBL:ENSMUSG00000003068
UNIPROT:Q9WTK7
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
20869
4
10
14912 bp
49.27
21
32
Stk11 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
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CDS(bp)
Protein
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Name
MGI
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