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Stk11 - serine/threonine kinase 11

Alias:
Lkb1
Par-4
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码丝氨酸/苏氨酸激酶家族的一员。编码的蛋白质是一种已知的肿瘤抑制子,通过磷酸化激活腺苷酸单磷酸激活的蛋白激酶(AMPK)和AMPK相关激酶蛋白质。AMPK途径的上游调节被认为可以调节许多不同的过程,包括细胞代谢、细胞极性、凋亡和DNA损伤反应。人类中类似基因的突变与Peutz-Jeghers综合症有关。可选的剪接导致多个转录变异体,包括在精子发生中可能发挥潜在作用的S异构体。[由RefSeq,2014年9月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
4
10
14912 bp
49.27
21
32

Stk11 Genetics information (+)

GRCm39

Sequence Homology

Transcripts & Proteins

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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
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