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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Stat3 - signal transducer and activator of transcription 3
Alias:
Aprf
1110034C02Rik
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质是STAT蛋白质家族的一员。响应细胞因子和生长因子,STAT家族成员被受体相关激酶磷酸化,然后形成同源或异源二聚体,转移到细胞核中作为转录激活子发挥作用。这个蛋白质通过磷酸化被激活,响应各种细胞因子和生长因子,包括IFNs、EGF、IL5、IL6、HGF、LIF和BMP2。这个蛋白质调节响应细胞刺激的各种基因的表达,因此在许多细胞过程中,如细胞生长和凋亡中扮演关键角色。已显示小GTP酶Rac1结合并调节这个蛋白质的活性。PIAS3蛋白质是这个蛋白质的特异性抑制剂。选择性剪接导致编码不同异构体的多种转录变异体。[RefSeq,2015年9月提供]
Related ID:
NCBI:20848
ENSEMBL:ENSMUSG00000004040
UNIPROT:P42227
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
20848
4
24
52816 bp
88.05
23
37
Stat3 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
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Cell-specific RNA expression
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Interactions
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Acting
Regulation
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Type
Name
MGI
Strain of Origin
Publications
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References Literature
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PMID
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Year
IF
No Data Found!
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