小鼠

Stat3 - signal transducer and activator of transcription 3

Alias:
Aprf
1110034C02Rik
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质是STAT蛋白质家族的一员。响应细胞因子和生长因子,STAT家族成员被受体相关激酶磷酸化,然后形成同源或异源二聚体,转移到细胞核中作为转录激活子发挥作用。这个蛋白质通过磷酸化被激活,响应各种细胞因子和生长因子,包括IFNs、EGF、IL5、IL6、HGF、LIF和BMP2。这个蛋白质调节响应细胞刺激的各种基因的表达,因此在许多细胞过程中,如细胞生长和凋亡中扮演关键角色。已显示小GTP酶Rac1结合并调节这个蛋白质的活性。PIAS3蛋白质是这个蛋白质的特异性抑制剂。选择性剪接导致编码不同异构体的多种转录变异体。[RefSeq,2015年9月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
4
24
52816 bp
88.05
23
37

Stat3 Genetics information (-)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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