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中文人类
ERN1 - Endoplasmic Reticulum To Nucleus Signaling 1
Alias:
IRE1
IRE1P
IRE1a
hIRE1p
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这个基因编码跨膜蛋白激酶肌醇需求酶1。编码的蛋白质包含两个功能催化结构域，一个丝氨酸/苏氨酸蛋白激酶结构域和一个内切核糖核酸酶结构域。这个蛋白质作为内质网（ER）中未折叠蛋白的传感器，并触发一个称为未折叠蛋白响应（UPR）的细胞内信号通路。UPR是酵母到哺乳动物保守的ER应激反应，激活涉及降解错误折叠蛋白、调节蛋白质合成和激活分子伴侣的基因。这个蛋白质特异性地调节应力反应转录因子X-盒结合蛋白1的剪接和激活。[由RefSeq，2017年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
ERN1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
