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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Srebf1 - sterol regulatory element binding transcription factor 1
Alias:
ADD1
SREBP1
bHLHd1
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个转录因子,它可以结合到固醇调节元件-1(SRE1)上,SRE1是一个低密度脂蛋白受体基因和一些涉及固醇生物合成的基因的十核苷酸基序。这个蛋白质作为一个前体被合成,然后附着在核膜和内质网上。在切割后,成熟的蛋白质会转移到核糖体中,并通过结合SRE1来激活转录。固醇会抑制前体的切割,成熟的核形式会被快速分解,从而减少转录。这个蛋白质是碱性螺旋-环-螺旋-亮氨酸拉链(bHLH-Zip)转录因子家族的成员。这个基因的替代剪接转录变体已经被表征。[由RefSeq,2017年11月提供]
Related ID:
NCBI:20787
ENSEMBL:ENSMUSG00000020538
UNIPROT:Q9WTN3
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
20787
8
19
23498 bp
120.54
7
22
Srebf1 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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