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中文小鼠
Sptlc2 - serine palmitoyltransferase, long chain base subunit 2
Alias:
LCB2
Spt2
LCB2a
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这个基因编码一种长链碱基亚基，是丝氨酸棕榈酰转移酶的关键酶。该酶由两个不同的亚基组成，是鞘脂生物合成的关键酶。它催化L-丝氨酸和棕榈酰-CoA在吡哆醇-5'-磷酸存在下缩合生成3-氧代鞘氨醇。小鼠中这个基因的突变等位基因被用作人类疾病“银屑病1易感性”的模型。人类基因中的突变与遗传性感觉神经病变I型有关。[RefSeq，2015年9月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
Sptlc2 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
References Literature
Title
PMID
Journal
Year
IF
