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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Sephs2 - selenophosphate synthetase 2
Alias:
Sps2
Ysg3
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种酶,该酶催化从硒化物和ATP产生单硒磷酸盐(MSP)。MSP是合成硒半胱氨酸(Sec)所需的硒供体,硒半胱氨酸是在读码框内UGA密码子处共翻译地结合到硒蛋白质中,该密码子通常作为翻译终止信号。硒蛋白质mRNA的3'UTR含有保守的茎环结构,即Sec插入序列(SECIS)元素,该元素对于识别UGA作为Sec密码子而不是作为停止信号是必要的。该蛋白质本身是一种含有活性位点Sec残基的硒蛋白质,这表明存在一种自调节机制。它优先在参与硒蛋白质合成的组织中和血细胞发育部位表达。[由RefSeq,2017年5月提供]
Related ID:
NCBI:20768
ENSEMBL:ENSMUSG00000049091
UNIPROT:P97364
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
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Reference
20768
1
1
2181 bp
47.83
3
5
Sephs2 Genetics information (-)
GRCm39
Sequence Homology
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* This data comes from NCBI.
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