Ncor2 - nuclear receptor co-repressor 2

Enables chromatin binding activity; sequence-specific DNA binding activity; and transcription corepressor activity. Acts upstream of or within several processes, including animal organ development; negative regulation of fat cell differentiation; and positive regulation of protein deacetylation. Located in nuclear body. Part of histone deacetylase complex. Is expressed in several structures, including branchial arch; central nervous system; limb; retina layer; and tooth. Used to study myelofibrosis. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human NCOR2 (nuclear receptor corepressor 2). [provided by Alliance of Genome Resources, Apr 2022]