Kdm5c - lysine (K)-specific demethylase 5C

Predicted to enable several functions, including histone H3-tri/di/monomethyl-lysine-4 demethylase activity; identical protein binding activity; and zinc ion binding activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within histone H3-K4 demethylation. Located in nucleus. Is expressed in several structures, including brain; early conceptus; gonad; limb; and metanephros. Used to study syndromic X-linked intellectual disability Claes-Jensen type. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Claes-Jensen type. Orthologous to human KDM5C (lysine demethylase 5C). [provided by Alliance of Genome Resources, Apr 2022]