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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Slfn4 - schlafen 4
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质属于Schlafen家族。这个家族的所有成员都含有一个位于AAA结构域附近的Schlafen盒结构域。这种蛋白质属于Schlafen蛋白质的2组,其分子量在58kDa和68kDa之间,并具有一个包含序列Ser-Trp-Ala-Asp-Leu的SWADL结构域。在恶性黑色素瘤细胞中,该基因的表达受到干扰素α的上调调节。在骨髓衍生的巨噬细胞中,该基因在Toll样受体激动剂激活期间表达被诱导,而在巨噬细胞集落刺激因子介导的分化期间表达受到抑制。在髓系谱系细胞中超表达会导致髓系生成受到破坏。该基因的一个假基因位于染色体11上。可变剪接导致多个转录变异体。[由RefSeq,2014年10月提供]
Related ID:
NCBI:20558
ENSEMBL:ENSMUSG00000000204
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
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Reference
20558
7
8
15042 bp
Unknown
6
8
Slfn4 Genetics information (+)
GRCm39
Sequence Homology
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* This data comes from NCBI.
Gene Expression
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