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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Sin3a - transcriptional regulator, SIN3A (yeast)
Alias:
Sin3
mSin3A
mKIAA4126
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种蛋白质,具有多种功能,包括与RNA聚合酶II特异性的DNA结合的转录因子结合活性,染色质结合活性,以及转录核心抑制物活性。该蛋白参与多种过程,包括大脑皮层神经元的分化,生物钟的负调控,以及轴突延伸的调控。它还在一些过程的上游或内部发挥作用,包括对葡萄糖刺激的反应,有丝分裂细胞循环的G2/M过渡的正调控,以及对甲基乙二醛的反应。该基因位于动粒和细胞核中,是转录抑制物复合物的一部分。它在几个结构中表达,包括中枢神经系统,早期胚泡,生殖泌尿系统和视网膜。这个基因的人类同源物与15号染色体q24缺失综合征有关。该基因与人类SIN3A(SIN3转录调节因子家族成员A)正交。[由基因组资源联盟,2022年4月提供]
Related ID:
NCBI:20466
ENSEMBL:ENSMUSG00000042557
UNIPROT:Q60520
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
20466
16
22
56382 bp
145.09
5
31
Sin3a Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
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Cell-specific RNA expression
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Interactions
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Acting
Regulation
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Type
Name
MGI
Strain of Origin
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References Literature
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