Sorbs1 - sorbin and SH3 domain containing 1

Enables enzyme binding activity; insulin receptor binding activity; and signaling receptor complex adaptor activity. Involved in several processes, including focal adhesion assembly; positive regulation of biosynthetic process; and positive regulation of glucose import. Acts upstream of or within acetylcholine receptor signaling pathway and regulation of skeletal muscle acetylcholine-gated channel clustering. Located in several cellular components, including adherens junction; nuclear matrix; and stress fiber. Part of flotillin complex. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human SORBS1 (sorbin and SH3 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]