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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Selenow - selenoprotein W
Alias:
selW
Sepw1
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
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References Literature
该基因编码一种含有硒半胱氨酸(Sec)残基的硒蛋白,该残基由正常作为翻译终止信号的UGA密码子编码。硒蛋白mRNA的3'UTR含有保守的茎环结构,即Sec插入序列(SECIS)元素,该元素对于将UGA识别为Sec密码子而非终止信号是必要的。该蛋白在骨骼肌和大脑中高度表达。它属于SelWTH家族,该家族具有类似硫氧还蛋白的折叠结构和一个保守的CxxU(C是半胱氨酸,U是Sec)基序,已被证明在体内具有谷胱甘肽依赖的抗氧化功能。小鼠研究提示,该硒蛋白参与肌肉生长和分化,以及保护神经元免受神经发育过程中的氧化应激。[RefSeq,2017年4月提供]
Related ID:
NCBI:20364
ENSEMBL:ENSMUSG00000041571
UNIPROT:P63300
Basic Information
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Transcripts
Exons
Length
MW (kDa)
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Reference
20364
1
6
5164 bp
9.69
8
8
Selenow Genetics information (-)
GRCm39
Sequence Homology
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* This data comes from NCBI.
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