Log In|Sign Up
中文人类
EP300 - E1A Binding Protein P300
Alias:
p300
KAT3B
MKHK2
RSTS2
加入收藏
这个基因编码腺病毒E1A相关的细胞p300转录共激活蛋白。它作为组蛋白乙酰转移酶，通过染色质重塑调控转录，并在细胞增殖和分化的过程中发挥重要作用。它通过特异性地结合磷酸化的CREB蛋白，调节cAMP基因的调控。这个基因还被鉴定为HIF1A（低氧诱导因子1α）的共激活子，因此在刺激低氧诱导的基因如VEGF方面发挥作用。这个基因的缺陷是导致Rubinstein-Taybi综合征的原因，也可能在上皮癌症中发挥作用。[RefSeq,2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
EP300 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
