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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Nr1h4 - nuclear receptor subfamily 1, group H, member 4
Alias:
Fxr
HRR1
RIP14
Rxrip14
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
激活DNA结合转录因子活性,特异性为RNA聚合酶II;胆汁酸结合活性;和类视黄醇X受体结合活性。参与几个过程,包括脂质内稳态;细胞因子产生的负调控;和信号传导的调控。在几个过程的上游或内部发挥作用,包括Notch信号通路;胆汁酸代谢过程;和极低密度脂蛋白颗粒重塑的负调控。预测位于常染色质和细胞核中。预测是受体复合物的一部分。在几个结构中表达,包括第一鳃弓;中枢神经系统;肝脏;感觉器官;和泌尿系统。用于研究肝细胞癌。该基因的人类同源物与肝外胆汁郁积;肝细胞癌;和进行性家族性肝内胆汁郁滞5有关。与人类NR1H4(核受体亚家族1H成员4)正交。[由基因组资源联盟,2022年4月提供]
Related ID:
NCBI:20186
ENSEMBL:ENSMUSG00000047638
UNIPROT:Q60641
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
20186
6
9
79389 bp
55.99
13
45
Nr1h4 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Type
Name
MGI
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References Literature
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