Enables DNA binding activity and DNA-binding transcription factor activity. Contributes to nuclear receptor activity and transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; regulation of branching involved in prostate gland morphogenesis; and regulation of cellular macromolecule biosynthetic process. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and sensory organ. Used to study congenital heart disease; dilated cardiomyopathy; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RXRA (retinoid X receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]