Predicted to enable NEDD8 ligase activity; cullin family protein binding activity; and ubiquitin protein ligase activity. Acts upstream of or within several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; brain development; and intrinsic apoptotic signaling pathway in response to oxidative stress. Located in cytoplasm and nucleus. Is expressed in brain; eye; and genitourinary system. Orthologous to human RNF7 (ring finger protein 7). [provided by Alliance of Genome Resources, Apr 2022]