Rlim - ring finger protein, LIM domain interacting

Enables ubiquitin protein ligase activity. Involved in protein ubiquitination; random inactivation of X chromosome; and ubiquitin-dependent protein catabolic process. Acts upstream of or within negative regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; and regulation of dosage compensation by inactivation of X chromosome. Located in nucleus. Is expressed in several structures, including extraembryonic component; limb; liver; male reproductive system; and urinary system. Human ortholog(s) of this gene implicated in Tonne-Kalscheuer syndrome. Orthologous to human RLIM (ring finger protein, LIM domain interacting). [provided by Alliance of Genome Resources, Apr 2022]