Enables transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including Peyer's patch morphogenesis; neuron cell-cell adhesion; and positive regulation of metanephric glomerulus development. Acts upstream of or within several processes, including animal organ development; nervous system development; and positive regulation of macromolecule metabolic process. Predicted to be located in several cellular components, including endosome; membrane raft; and neuronal cell body. Predicted to be part of plasma membrane protein complex and receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including branchial arch; genitourinary system; gut; nervous system; and sensory organ. Used to study Hirschsprung's disease; clubfoot; multiple endocrine neoplasia type 2B; and pheochromocytoma. Human ortholog(s) of this gene implicated in Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (ret proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]