Rbpj - recombination signal binding protein for immunoglobulin kappa J region

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein N-terminus binding activity. Involved in several processes, including circulatory system development; positive regulation of signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and regulation of transcription, DNA-templated. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; neural ectoderm; paraxial mesenchyme; and retina. Used to study aortic valve disease. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region). [provided by Alliance of Genome Resources, Apr 2022]