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中文人类
EGFR - Epidermal Growth Factor Receptor
Alias:
ERBB
ERRP
HER1
mENA
ERBB1
PIG61
NISBD2
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这个基因编码的蛋白质是一种跨膜糖蛋白，属于蛋白激酶超家族成员。这个蛋白质是表皮生长因子家族的受体。EGFR 是一种细胞表面蛋白质，与表皮生长因子结合，从而诱导受体二聚化和酪氨酸自磷酸化，导致细胞增殖。这个基因的突变与肺癌有关。EGFR 是细胞因子风暴的成分，细胞因子风暴有助于由严重急性呼吸综合症冠状病毒-2（SARS-CoV-2）感染引起的2019年冠状病毒病（COVID-19）的严重形式。[由RefSeq，2020年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
EGFR Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
