Pura - purine rich element binding protein A

Enables several functions, including SMAD binding activity; nucleic acid binding activity; and transcription regulator inhibitor activity. Involved in dendritic transport of messenger ribonucleoprotein complex; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including epithelial cell proliferation; lymphocyte proliferation; and positive regulation of cell population proliferation. Located in several cellular components, including dendrite; neuronal cell body; and nucleus. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and nervous system. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 31. Orthologous to human PURA (purine rich element binding protein A). [provided by Alliance of Genome Resources, Apr 2022]