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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Ptpn22 - protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Alias:
PEP
Ptpn8
70zpep
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
激活SH3结构域结合活性和激酶结合活性。参与几个过程,包括调节T细胞激活;调节细胞因子产生;以及调节信号传导。在T细胞分化上游或内部发挥作用;T细胞受体信号通路;以及蛋白质脱磷酸化。位于细胞质;质膜的细胞质侧;以及核内。在背根神经节;周围神经系统;和胸腺原基中表达。这个基因的人类同源物涉及几种疾病,包括阿迪森病;梅尼埃病;自身免疫性疾病(多种);慢性淋巴细胞白血病;和肺结核。与人类PTPN22(非受体型蛋白酪氨酸磷酸酶22)正交。[由基因组资源联盟,2022年4月提供]
Related ID:
NCBI:19260
ENSEMBL:ENSMUSG00000027843
UNIPROT:P29352
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
19260
9
22
55678 bp
89.71
17
11
Ptpn22 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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