Prop1 - paired like homeodomain factor 1

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; beta-catenin binding activity; and protein C-terminus binding activity. Acts upstream of or within several processes, including canonical Wnt signaling pathway; diencephalon development; and regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in Rathke's pouch; adenohypophysis; adenohypophysis pars anterior; and pituitary gland. Used to study hypopituitarism. Human ortholog(s) of this gene implicated in hypogonadism; hypopituitarism; and panhypopituitarism. Orthologous to human PROP1 (PROP paired-like homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]