Mapk8ip1 - mitogen-activated protein kinase 8 interacting protein 1

Enables kinesin binding activity and protein kinase binding activity. Involved in positive regulation of JNK cascade and regulation of CD8-positive, alpha-beta T cell proliferation. Acts upstream of or within several processes, including JUN phosphorylation; negative regulation of intrinsic apoptotic signaling pathway; and regulation of transcription, DNA-templated. Located in several cellular components, including cell body; dendrite; and dentate gyrus mossy fiber. Is expressed in intestine smooth muscle circular layer; nervous system; renal vasculature; and sensory organ. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]