Prkdc - protein kinase, DNA activated, catalytic polypeptide

Enables DNA-dependent protein kinase activity; double-stranded DNA binding activity; and enzyme binding activity. Involved in several processes, including regulation of cellular protein metabolic process; regulation of hematopoietic stem cell differentiation; and regulation of hemopoiesis. Acts upstream of or within several processes, including DNA metabolic process; ectopic germ cell programmed cell death; and immune system development. Located in nucleus. Is expressed in several structures, including central nervous system; neural retina; and thymus primordium. Used to study severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Human ortholog(s) of this gene implicated in immunodeficiency 26. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]