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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Pparg - peroxisome proliferator activated receptor gamma
Alias:
Nr1c3
PPARgamma
PPAR-gamma
PPARgamma2
PPAR-gamma2
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Description
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种属于过氧化物酶体增殖物激活受体(PPAR)家族的核受体蛋白。编码的蛋白质是一种受配体激活的转录因子,参与调节脂肪细胞分化和血糖稳态。编码的蛋白质与类维生素A X受体形成异源二聚体,并结合称为“过氧化物酶体增殖反应元件”的DNA基序,以激活或抑制基因表达。缺乏编码的蛋白质的小鼠在胚胎阶段死亡,原因是胎盘血管化严重缺陷。当缺乏这个基因的胚胎用健康的胎盘补充时,突变体存活到足月,但死于脂肪营养不良和多发性出血。可变剪接产生多种转录变异体,编码不同的异构体。[由RefSeq,2015年4月提供]
Related ID:
NCBI:19016
ENSEMBL:ENSMUSG00000000440
UNIPROT:P37238
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
19016
10
8
129538 bp
57.60
39
27
Pparg Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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