小鼠

Plk1 - polo like kinase 1

Alias:
Plk
STPK13
Favorite
Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的Ser/Thr蛋白激酶属于CDC5/Polo亚家族。它在有丝分裂过程中高度表达,可能在S期的DNA复制中发挥作用。这个基因在所有胚胎组织中表达,但在成年组织中仅限于胸腺和卵巢。纯合子敲除小鼠是胚胎致命的,表明这个基因对早期胚胎发育很重要。这个基因被认为是一个潜在的癌基因,因为它在各种肿瘤和肿瘤细胞系中过度表达。在癌细胞中这个蛋白质的减少已被证明可以抑制细胞增殖和抑制癌基因转化;因此,它是癌症治疗的一个靶点。[RefSeq, 2015年9月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
1
10
10450 bp
68.30
10
18

Plk1 Genetics information (+)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
Wechat
Sequence
Comparison
Al agent
Tutorials
Back to top