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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Plk1 - polo like kinase 1
Alias:
Plk
STPK13
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的Ser/Thr蛋白激酶属于CDC5/Polo亚家族。它在有丝分裂过程中高度表达,可能在S期的DNA复制中发挥作用。这个基因在所有胚胎组织中表达,但在成年组织中仅限于胸腺和卵巢。纯合子敲除小鼠是胚胎致命的,表明这个基因对早期胚胎发育很重要。这个基因被认为是一个潜在的癌基因,因为它在各种肿瘤和肿瘤细胞系中过度表达。在癌细胞中这个蛋白质的减少已被证明可以抑制细胞增殖和抑制癌基因转化;因此,它是癌症治疗的一个靶点。[RefSeq, 2015年9月提供]
Related ID:
NCBI:18817
ENSEMBL:ENSMUSG00000030867
UNIPROT:Q07832
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
18817
1
10
10450 bp
68.30
10
18
Plk1 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
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