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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Serpine1 - serine (or cysteine) peptidase inhibitor, clade E, member 1
Alias:
PAI1
PAI-1
Planh1
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
具有丝氨酸型内肽酶抑制活性。参与对革兰阴性菌的防御反应;负调控血浆溶菌酶激活;以及调控血管生成。在几个过程的上游或内部发挥作用,包括对转化生长因子β刺激的细胞反应;胎盘发育;以及血管生成的调控。位于细胞外空间。在几个结构中表达,包括主动脉;胚外成分;肝脏;卵母细胞;和胎盘。用于研究冠状病毒感染性病变。这个基因的人类同源物与几种疾病有关,包括动脉疾病(多种);自身免疫疾病(多种);糖尿病性视网膜病变(多种);肝脏疾病(多种);和肺部疾病(多种)。与人类SERPINE1(丝氨酸蛋白酶抑制因子E成员1)正交。[由基因组资源联盟,2022年4月提供]
Related ID:
NCBI:18787
ENSEMBL:ENSMUSG00000037411
UNIPROT:P22777
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
18787
1
9
10769 bp
Unknown
7
1
Serpine1 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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