Home
Toolbox
Resource
Workflow
Tutorials
Citations
Downloads
Mutation Al-Predictor Flow
Gene-to-Mutation Flow
News & Insights
Genetic Encyclopedia
Frontiers
Industry Insights
Case Studies
About Us
About the Site
Contact Us
Private Policy
User Agreement
COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
Log In
|
Sign Up
中文
小鼠
Pla2g4a - phospholipase A2, group IVA (cytosolic, calcium-dependent)
Alias:
cPLA2
Pla2g4
cPLA2alpha
cPLA2-alpha
Create a favorites folder
Cancel
Confirm
Add To Favorites
Select a favorites
Description
New favorites >>
Cancel
Confirm
Favorite
Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质是磷脂酶A2 IV组的成员。这种酶水解膜磷脂,从而释放多不饱和脂肪酸,如花生四烯酸。花生四烯酸进一步代谢成前列腺素、血栓素和白细胞三烯等类二十烷酸,它们在调节多种生物过程(如炎症反应、膜和肌动蛋白动力学以及肿瘤发生)中起着重要作用。细胞内钙水平的升高导致钙结合到这个蛋白质的C2结构域,并触发其从细胞质到细胞膜(包括高尔基体)的易位。小鼠中这个基因的破坏导致类二十烷酸和血小板激活因子水平降低,过敏症状减轻,以及雌性动物的生殖能力受损。可变剪接导致多个转录变异体,编码不同的异构体。[RefSeq,2015年3月提供]
Related ID:
NCBI:18783
ENSEMBL:ENSMUSG00000056220
UNIPROT:P47713
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
18783
2
18
131673 bp
85.22
7
17
Pla2g4a Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Reset
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
Wechat
Sequence
Comparison
Al agent
Tutorials
Back to top