Pip5k1c - phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and talin binding activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization and regulation of synaptic vesicle endocytosis. Acts upstream of or within axonogenesis; phosphatidylinositol biosynthetic process; and platelet aggregation. Located in cytosol and postsynaptic density. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 3. Orthologous to human PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma). [provided by Alliance of Genome Resources, Apr 2022]