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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
E2F2 - E2F Transcription Factor 2
Alias:
E2F-2
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是E2F家族转录因子的成员。E2F家族在控制细胞周期和肿瘤抑制蛋白的作用中起着至关重要的作用,也是小DNA肿瘤病毒的转化蛋白的目标。E2F蛋白包含几个在家族中大多数成员中发现的进化上保守的域。这些域包括一个DNA结合域,一个二聚化域,该域决定了与分化调节转录因子蛋白(DP)的相互作用,一个富含酸性氨基酸的转录激活域,以及一个嵌入转录激活域的肿瘤抑制蛋白结合域。这个蛋白质和其他两个成员,E2F1和E2F3,有一个额外的周期蛋白结合域。这个蛋白质以细胞周期依赖的方式特异性地与视网膜母细胞瘤蛋白pRB结合,并且与E2F1相比,它在氨基酸序列上具有46%的整体同源性。[由RefSeq提供,2008年7月]
Related ID:
NCBI:1870
ENSEMBL:ENSG00000007968
HGNC:3114
UNIPROT:Q14209
OMIM:600426
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
1870
10
7
26022 bp
47.51
22
--
3
7
E2F2 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
No data available
Transcripts & Proteins
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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.
Gene Expression
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Type
Name
MGI
Strain of Origin
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No data available
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Name
CAS Number
Status
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Link
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References Literature
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