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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Pea15a - proliferation and apoptosis adaptor protein 15A
Alias:
Mat1
Pea15
PEA-15
Pkcs15
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个适配器蛋白,作为通过与其死亡域和caspase-8相互作用的负调控因子,调节肿瘤坏死因子-α、肿瘤坏死因子相关凋亡诱导配体以及Fas诱导的凋亡。它还可以通过将细胞外信号调节蛋白激酶1和2重新定位到细胞质来调节增殖信号。这个基因编码的蛋白质含有N-末端死亡效应子结构域和一个长而灵活的C-末端尾。在人类中,这个基因编码的蛋白质是蛋白激酶C的内源性底物。这个蛋白质在2型糖尿病患者中过度表达,可能参与葡萄糖摄取的胰岛素抵抗。这个基因的多个假基因已经被识别。选择性剪接产生了多种转录变异体。[RefSeq,2016年8月提供]
Related ID:
NCBI:18611
ENSEMBL:ENSMUSG00000013698
UNIPROT:Q62048
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
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Reference
18611
4
4
10077 bp
15.05
3
8
Pea15a Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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