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Pea15a - proliferation and apoptosis adaptor protein 15A

Alias:
Mat1
Pea15
PEA-15
Pkcs15
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个适配器蛋白,作为通过与其死亡域和caspase-8相互作用的负调控因子,调节肿瘤坏死因子-α、肿瘤坏死因子相关凋亡诱导配体以及Fas诱导的凋亡。它还可以通过将细胞外信号调节蛋白激酶1和2重新定位到细胞质来调节增殖信号。这个基因编码的蛋白质含有N-末端死亡效应子结构域和一个长而灵活的C-末端尾。在人类中,这个基因编码的蛋白质是蛋白激酶C的内源性底物。这个蛋白质在2型糖尿病患者中过度表达,可能参与葡萄糖摄取的胰岛素抵抗。这个基因的多个假基因已经被识别。选择性剪接产生了多种转录变异体。[RefSeq,2016年8月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
4
4
10077 bp
15.05
3
8

Pea15a Genetics information (-)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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