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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Pdgfra - platelet derived growth factor receptor, alpha polypeptide
Alias:
CD140a
Pdgfr-2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种受体酪氨酸激酶家族的蛋白质成员。血小板来源的生长因子蛋白质配体结合到这个受体上会触发受体的二聚化和自磷酸化,从而导致几个下游信号通路被激活。通过编码的受体的信号传导在胃胚形成和几乎所有器官系统的发育中发挥作用。据报道,缺乏这个基因功能拷贝的小鼠在肺、骨骼、睾丸和中枢神经系统方面表现出缺陷,并在出生后不久死亡。基因转录本的替代剪接和内含子多腺苷化与成年小鼠的肌肉再生和纤维化有关。[由RefSeq,2017年1月提供]
Related ID:
NCBI:18595
ENSEMBL:ENSMUSG00000029231
UNIPROT:P26618
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
18595
7
23
46880 bp
122.68
33
13
Pdgfra Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
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