人类

DUSP4 - Dual Specificity Phosphatase 4

Alias:
TYP
HVH2
MKP2
MKP-2
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是双特异性蛋白磷酸酶亚家族的一员。这些磷酸酶通过去除磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基来使它们的靶标激酶失活。它们负调节有丝分裂激活蛋白(MAP)激酶超家族(MAPK/ERK、SAPK/JNK、p38)的成员,这些成员与细胞增殖和分化有关。双特异性磷酸酶家族的不同成员显示出对各种MAP激酶、不同的组织分布和亚细胞定位以及它们表达的外部刺激的不同诱导方式的不同的底物特异性。这个基因产物抑制ERK1、ERK2和JNK,在各种组织中表达,并定位在核中。已经观察到了这个基因的两个可变剪接转录变异体,它们编码不同的异构体。此外,已经报道了多个聚腺苷酸化位点。[由RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
2
4
17621 bp
42.95
12
--
9
11

DUSP4 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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