人类

DUSP3 - Dual Specificity Phosphatase 3

Alias:
VHR
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是双特异性蛋白磷酸酶亚家族的一员。这些磷酸酶通过去除磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基来抑制其靶定激酶。它们负调控有丝分裂激活蛋白(MAP)激酶超家族(MAPK/ERK,SAPK/JNK,p38)的成员,这些成员与细胞增殖和分化有关。双特异性磷酸酶家族的不同成员显示出对各种MAP激酶、不同的组织分布和亚细胞定位以及不同的细胞外刺激对其表达诱导方式的不同的底物特异性。这个基因位于包含BRCA1基因座的一个区域,该基因座导致乳腺癌和卵巢癌的易感性。尽管DUSP3在乳腺和卵巢组织中都有表达,但在乳腺癌系和散发肿瘤中的突变筛查结果是阴性,从而导致结论是此基因不是BRCA1。[由RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
1
3
12853 bp
20.48
4
--
5
8

DUSP3 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
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