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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
DUSP3 - Dual Specificity Phosphatase 3
Alias:
VHR
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是双特异性蛋白磷酸酶亚家族的一员。这些磷酸酶通过去除磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基来抑制其靶定激酶。它们负调控有丝分裂激活蛋白(MAP)激酶超家族(MAPK/ERK,SAPK/JNK,p38)的成员,这些成员与细胞增殖和分化有关。双特异性磷酸酶家族的不同成员显示出对各种MAP激酶、不同的组织分布和亚细胞定位以及不同的细胞外刺激对其表达诱导方式的不同的底物特异性。这个基因位于包含BRCA1基因座的一个区域,该基因座导致乳腺癌和卵巢癌的易感性。尽管DUSP3在乳腺和卵巢组织中都有表达,但在乳腺癌系和散发肿瘤中的突变筛查结果是阴性,从而导致结论是此基因不是BRCA1。[由RefSeq,2008年7月提供]
Related ID:
NCBI:1845
ENSEMBL:ENSG00000108861
HGNC:3069
UNIPROT:P51452
OMIM:600183
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
1845
1
3
12853 bp
20.48
4
--
5
8
DUSP3 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
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No data available
Transcripts & Proteins
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Transcript
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Protein
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No data available
* This data comes from NCBI.
Gene Expression
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Name
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References Literature
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