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中文人类
AGT - Angiotensinogen
Alias:
ANHU
hFLT1
SERPINA8
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这个基因编码的蛋白质，即预血管紧张素原或血管紧张素原前体，在肝脏中表达，并受到酶肾素的切割，以应对降低的血压。产生的产物，即血管紧张素I，然后被血管紧张素转换酶（ACE）切割，生成具有生理活性的酶血管紧张素II。该蛋白质参与维持血压、体内液体和电解质的平衡，以及原发性高血压和子痫前期的发病机制。这个基因的突变与原发性高血压的易感性有关，并可能导致肾小管发育不良，这是一种严重的肾小管发育紊乱。这个基因的缺陷也与非家族性心房纤颤和炎症性肠病有关。[RefSeq, Nov 2019提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
AGT Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
