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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Oprk1 - opioid receptor, kappa 1
Alias:
KOR
R21
KOR-1
MSL-1
Oprk2
K-OR-1
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种阿片受体,属于7次跨膜的G蛋白耦合受体家族。它作为内源配体受体,以及各种合成阿片受体的受体。配体结合导致腺苷酸环化酶活性抑制和神经递质释放。这个阿片受体在疼痛感知和调节合成阿片药的镇静、镇痛和厌恶作用中发挥作用。这个基因的变异也与酒精依赖和阿片成瘾有关。已经发现了这个基因的可变剪接转录变异体。最近的一项研究提供了这个基因中翻译读穿的证据,以及通过使用替代的帧内翻译终止密码子表达额外的C端延伸的异构体。[由RefSeq,2017年12月提供]
Related ID:
NCBI:18387
ENSEMBL:ENSMUSG00000025905
UNIPROT:P33534
Basic Information
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Transcripts
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Length
MW (kDa)
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18387
4
4
17685 bp
42.65
14
13
Oprk1 Genetics information (+)
GRCm39
Sequence Homology
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* This data comes from NCBI.
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