Enables guanylate cyclase activity. Predicted to be involved in several processes, including cGMP biosynthetic process; positive regulation of cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; limb; and respiratory system. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human NPR1 (natriuretic peptide receptor 1). [provided by Alliance of Genome Resources, Apr 2022]