Npm1 - nucleophosmin 1

Enables identical protein binding activity; protein N-terminus binding activity; and rRNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and protein stabilization. Acts upstream of or within several processes, including positive regulation of protein modification process; regulation of gene expression; and ribosome biogenesis. Located in centrosome; cytosol; and nuclear lumen. Part of large ribosomal subunit and small ribosomal subunit. Is expressed in several structures, including central nervous system; early conceptus; oocyte; and small intestine crypt of lieberkuhn. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1). [provided by Alliance of Genome Resources, Apr 2022]