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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Notch4 - notch 4
Alias:
N4
Int3
Int-3
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
使Notch结合活性正常。参与血管分支、血管形态发生和对内皮细胞分化的负调控。在几个过程的上游或内部发挥作用,包括Notch信号通路负调控、血管生成正调控和主动脉形态发生正调控。位于细胞质囊泡和内质网中。在几个结构中表达,包括大脑、心血管系统、生殖泌尿系统、肠道和血淋巴系统腺体。用于研究脑动脉静脉畸形。该基因的人类同源物涉及自身免疫性疾病(多种)、痴呆、导管原位癌、精神分裂症和系统性硬皮病。与人类NOTCH4(notch受体4)正交。[由基因组资源联盟,2022年4月提供]
Related ID:
NCBI:18132
ENSEMBL:ENSMUSG00000015468
UNIPROT:P31695
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
18132
3
30
24261 bp
206.70
8
11
Notch4 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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Name
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