Notch2 - notch 2

Enables NF-kappaB binding activity and enzyme binding activity. Involved in several processes, including heart looping; left/right axis specification; and marginal zone B cell differentiation. Acts upstream of or within several processes, including animal organ development; cholangiocyte proliferation; and positive regulation of BMP signaling pathway. Located in cilium and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Hajdu-Cheney syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2). [provided by Alliance of Genome Resources, Apr 2022]