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中文人类
DR1 - Down-regulator Of Transcription 1
Alias:
NC2
NC2B
NCB2
NC2-BETA
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这个基因编码一个与TBP（TATA盒结合蛋白）关联的磷酸化蛋白，该蛋白可以抑制转录的基线和激活水平。编码的蛋白质在体内被磷酸化，这种磷酸化影响其与TBP的相互作用。该蛋白质在氨基末端含有一个组蛋白折叠模版，一个TBP结合域和一个富含谷氨酰胺和丙氨酸的区域。DR1阻遏复合物与TBP启动子复合物的结合可能建立了一种机制，即改变的DNA构象，以及形成更高阶的复合物，抑制预起始复合物的组装并控制RNA聚合酶II转录的速率。[由RefSeq提供，2008年7月]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
DR1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
