Nfib - nuclear factor I/B

Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including lung epithelial cell differentiation; negative regulation of cell population proliferation; and nervous system development. Acts upstream of or within several processes, including animal organ development; positive regulation of transcription by RNA polymerase II; and response to bacterium. Located in cerebellar mossy fiber and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and respiratory system. Orthologous to human NFIB (nuclear factor I B). [provided by Alliance of Genome Resources, Apr 2022]