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中文人类
DNMT1 - DNA Methyltransferase 1
Alias:
AIM
DNMT
MCMT
CXXC9
HSN1E
ADCADN
m.HsaI
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这个基因编码一种将甲基基团转移到基因组DNA的胞嘧啶核苷酸中的酶。这种蛋白质是负责在DNA复制后维持甲基化模式的主要酶，并显示对半甲基化DNA的偏好。DNA的甲基化是哺乳动物表观遗传基因调控的重要成分。异常的甲基化模式在人类肿瘤中发现，并与发育异常相关。这个基因的变异与小脑性共济失调、耳聋和嗜睡症以及遗传性感觉神经病变，类型IE有关。可选的剪接导致多个转录变异体。[由RefSeq，2016年1月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
DNMT1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
