Msx2 - msh homeobox 2

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription regulatory region DNA binding activity; negative regulation of transcription, DNA-templated; and osteoblast differentiation. Acts upstream of or within several processes, including animal organ development; embryonic limb morphogenesis; and regulation of gene expression. Part of transcription regulator complex. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; genitourinary system; jaw; and sensory organ. Used to study craniosynostosis and parietal foramina. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Orthologous to human MSX2 (msh homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]