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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Mmp13 - matrix metallopeptidase 13
Alias:
Clg
Mmp1
MMP-13
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码基质金属蛋白酶家族的一员,在伤口愈合、骨骼发育和骨重塑中发挥作用。编码的蛋白质通过移除N-端激活肽而被激活,生成一个依赖锌的内肽酶,可以切割各种天然的胶原蛋白,包括I型-IV型、X型和XIV型。缺乏编码的蛋白质的小鼠在生长板软骨中表现出严重的缺陷,以及软骨内骨发育的延迟。缺乏编码的蛋白质还会损伤伤口愈合过程,因为伤口部位的角质细胞迁移和血管密度减少。这个基因位于染色体9上的其他基质金属蛋白酶基因簇中。[RefSeq,2015年6月提供]
Related ID:
NCBI:17386
ENSEMBL:ENSMUSG00000050578
UNIPROT:P33435
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
17386
1
10
10820 bp
54.18
9
14
Mmp13 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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